It seems like the text is suggesting that being “very unreasonable” or “very wrongful” might cause a person to lose their significance or value in the eyes of others, including entities or beings from a higher realm. This could potentially lead to feelings of isolation or detachment from others, as they may see the individual as being immoral or unethical. However, it’s important to note that this is just one perspective and doesn’t necessarily reflect reality. Other factors such as personal values, beliefs, and actions also play a role in how others perceive us.